The Chisholm Trail was the major route out of Texas for livestock.
Although it was used only from 1867 to 1884, the longhorn cattle driven north along it provided a steady source of income that helped the impoverished state recover from the Civil War. Youthful trail hands on mustangs gave a Texas flavor to the entire range cattle industry of the Great Plains and made the cowboy an enduring folk hero.

When the Civil War ended, the state's only potential assets were its countless longhorns, for which no market was available—Missouri and Kansas had closed their borders to Texas cattle in the 1850s because of the deadly Texas fever they carried. In the East was a growing demand for beef, and many men, among them Joseph G. McCoy of Illinois, sought ways of supplying it with Texas cattle. In the spring of 1867 he persuaded Kansas Pacific officials to lay a siding at the hamlet of Abilene, Kansas, on the edge of the quarantine area. He began building pens and loading facilities.

The first herd to follow the future Chisholm Trail to Abilene belonged to O. W. Wheeler and his partners, who in 1867 bought 2,400 steers in San Antonio. They planned to winter them on the plains, then trail them on to California. At the North Canadian River in Indian Territory they saw wagon tracks and followed them. The tracks were made by Scot-Cherokee Jesse Chisholm, who in 1864 began hauling trade goods to Indian camps about 220 miles south of his post near modern Wichita.
At first the route was merely referred to as the Trail, the Kansas Trail, the Abilene Trail, or McCoy's Trail. Though it was originally applied only to the trail north of the Red River, Texas cowmen soon gave Chisholm's name to the entire trail from the Rio Grande to central Kansas. The earliest known references to the Chisholm Trail in print were in the Kansas Daily Commonwealth of May 27 and October 11, 1870.

The herds followed the old Shawnee Trail by way of San Antonio, Austin, and Waco, where the trails split. The Chisholm Trail continued on to Fort Worth, then passed east of Decatur to the crossing at Red River Station. From Fort Worth to Newton, Kansas, U.S. Highway 81 follows the Chisholm Trail.
Between 1871, when Abilene ceased to be a cattle market, and 1884 the trail might end at Ellsworth, Junction City, Newton, Wichita, or Caldwell. The Western Trail by way of Fort Griffin and Doan's Store ended at Dodge City.
The cattle did not follow a clearly defined trail except at river crossings; when dozens of herds were moving north it was necessary to spread them out to find grass. The animals were allowed to graze along for ten or twelve miles a day and never pushed except to reach water; cattle that ate and drank their fill were unlikely to stampede.
When conditions were favorable longhorns actually gained weight on the trail.
After trailing techniques were perfected, a trail boss, ten cowboys, a cook, and a horse wrangler could trail 2,500 cattle three months for sixty to seventy-five cents a head. This was far cheaper than shipping by rail.
From: TSHA - Texas State Historical Association